TheHCP5Single‐Nucleotide Polymorphism: A Simple Screening Tool for Prediction of Hypersensitivity Reaction to Abacavir | Zendy

Sara Colombo | Zendy; Andri Rauch | Zendy; Margalida Rotger | Zendy; Jacques Fellay | Zendy; Raquel Martínez | Zendy; Christoph A. Fux | Zendy; Christine Thurnheer | Zendy; Huldrych F. Günthard | Zendy; David B. Goldstein | Zendy; Hansjakob Furrer | Zendy; Amalio Telenti | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

TheHCP5Single‐Nucleotide Polymorphism: A Simple Screening Tool for Prediction of Hypersensitivity Reaction to Abacavir

Author(s) -

Sara Colombo,

Andri Rauch,

Margalida Rotger,

Jacques Fellay,

Raquel Martínez,

Christoph A. Fux,

Christine Thurnheer,

Huldrych F. Günthard,

David B. Goldstein,

Hansjakob Furrer,

Amalio Telenti

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591184

Subject(s) - abacavir , genotyping , biology , single nucleotide polymorphism , typing , snp , genetics , linkage disequilibrium , hla b antigens , human leukocyte antigen , allele , snp genotyping , genotype , viral load , virus , antigen , antiretroviral therapy , gene

The HLA-B 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed "ABC-HSR." This study of 1,103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide polymorphism (SNP), rs2395029, in relation to ABC-HSR. In populations with European ancestry, rs2395029 is in linkage disequilibrium with HLA-B 5701. The HCP5 SNP was present in all 98 HLA-B 5701-positive individuals and was absent in 999 of 1005 HLA-B 5701-negative individuals. rs2395029 was overrepresented in 25 individuals with clinically likely ABC-HSR, compared with its frequency in 175 ABC-tolerant individuals (80% vs. 2%, respectively; P < .0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research