Role of Nitric Oxide in Defense of the Central Nervous System againstMycobacterium tuberculosis | Zendy

Michael R. Olin | Zendy; Aníbal G. Armién | Zendy; Maxim C.J. Cheeran | Zendy; R. Bryan Rock | Zendy; Thomas W. Molitor | Zendy; Phillip K. Peterson | Zendy

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Role of Nitric Oxide in Defense of the Central Nervous System againstMycobacterium tuberculosis

Author(s) -

Michael R. Olin,

Aníbal G. Armién,

Maxim C.J. Cheeran,

R. Bryan Rock,

Thomas W. Molitor,

Phillip K. Peterson

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591097

Subject(s) - meninges , nitric oxide , nitric oxide synthase , mycobacterium tuberculosis , tuberculosis , immunology , tuberculous meningitis , central nervous system , knockout mouse , biology , microbiology and biotechnology , pathology , medicine , neuroscience , receptor , biochemistry , endocrinology

Murine models of tuberculous meningitis (TBM) have not reflected the severity of disease in humans. Based on reports that activated murine microglial cells, but not human microglial cells, express inducible nitric oxide synthase (iNOS), the objective of this study was to determine whether iNOS-knockout (iNOS(-/-)) mice would provide such a model. iNOS(-/-) mice infected with M. tuberculosis developed serious clinical manifestations and granulomatous lesions containing tubercle bacilli throughout the meninges, all of which were absent in wild-type mice. This study underscores the importance of nitric oxide in defense against TBM and suggests that iNOS(-/-) mice are an appropriate model for human TBM.

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