A Functional Toll‐Like Receptor 8 Variant Is Associated with HIV Disease Restriction
Author(s) -
DjinYe Oh,
Stefan Taube,
Osamah Hamouda,
Claudia Kücherer,
G Poggensee,
Heiko Jessen,
Jana Eckert,
Konrad Neumann,
Andreas Storek,
Marc Pouliot,
P Borgeat,
Na Ri Oh,
E. Schreier,
Axel Pruß,
Kim Hattermann,
R. R. Schumann
Publication year - 2008
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/590431
Subject(s) - biology , immunology , immune system , innate immune system , population , toll like receptor , virus , virology , genotype , receptor , gene , genetics , medicine , environmental health
Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR8 has been found to recognize RNA derived from various viruses, including human immunodeficiency virus (HIV). Presently, very little is known about the influence of TLR8 genetic variation on susceptibility to and progression of HIV disease.
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