Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations | Zendy

Tsin Wen Yeo | Zendy; Daniel A. Lampah | Zendy; Retno Gitawati | Zendy; Emiliana Tjitra | Zendy; Enny Kenangalem | Zendy; Yvette McNeil | Zendy; Christabelle J. Darcy | Zendy; Donald L. Granger | Zendy; J. Brice Weinberg | Zendy; Bert K. Lopansri | Zendy; Ric N. Price | Zendy; Stephen B. Duffull | Zendy; David S. Celermajer | Zendy; Nicholas M. Anstey | Zendy

Open Access

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations

Author(s) -

Tsin Wen Yeo,

Daniel A. Lampah,

Retno Gitawati,

Emiliana Tjitra,

Enny Kenangalem,

Yvette McNeil,

Christabelle J. Darcy,

Donald L. Granger,

J. Brice Weinberg,

Bert K. Lopansri,

Ric N. Price,

Stephen B. Duffull,

David S. Celermajer,

Nicholas M. Anstey

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/590209

Subject(s) - interquartile range , endothelial dysfunction , malaria , medicine , endothelial activation , parasitemia , lactic acidosis , acidosis , plasmodium falciparum , arginine , reactive hyperemia , nitric oxide , immunology , gastroenterology , endocrinology , endothelium , biology , biochemistry , blood flow , amino acid

Severe malaria is characterized by microvascular obstruction, endothelial dysfunction, and reduced levels of L-arginine and nitric oxide (NO). L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria.

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