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Severe malaria is characterized by microvascular obstruction, endothelial dysfunction, and reduced levels of L-arginine and nitric oxide (NO). L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasma<scp>l</scp>‐Arginine and Blood Lactate Concentrations

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations