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Trypanosoma cruzi infection (which causes Chagas disease) is typically undiagnosed and persists if untreated. We sought to affirm that T. cruzi-seropositive US blood donors have persistent infection with demonstrable parasitemia long after acquisition of infection. Fifty-two previously identified seropositive donors (positive by 2 methods) provided up to 3 blood specimens for testing by polymerase chain reaction (PCR) and hemoculture; most participants (67%) provided only 1 specimen. When evaluated 2 decades after immigration, 33 donors (63%) had PCR evidence of parasitemia; 3 also had culture-confirmed infection. This affirmation that bloodstream parasites are detectable--and potentially transmissible--decades after immigration strengthens the rationale for donor screening.

Trypanosoma cruziParasitemia in US Blood Donors with Serologic Evidence of Infection