Comparison of Virulence in Community‐Associated Methicillin‐ResistantStaphylococcus aureusPulsotypes USA300 and USA400 in a Rat Model of Pneumonia | Zendy

Christopher P. Montgomery | Zendy; Susan BoyleVavra | Zendy; Patricia Adem | Zendy; Jean C. Lee | Zendy; Aliya N. Husain | Zendy; Julia Clasen | Zendy; Robert S. Daum | Zendy

Open Access

Comparison of Virulence in Community‐Associated Methicillin‐ResistantStaphylococcus aureusPulsotypes USA300 and USA400 in a Rat Model of Pneumonia

Author(s) -

Christopher P. Montgomery,

Susan BoyleVavra,

Patricia Adem,

Jean C. Lee,

Aliya N. Husain,

Julia Clasen,

Robert S. Daum

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/590157

Subject(s) - virulence , staphylococcus aureus , microbiology and biotechnology , panton–valentine leukocidin , biology , leukocidin , toxin , pneumonia , methicillin resistant staphylococcus aureus , bacteria , medicine , gene , genetics

The predominant genetic background of community-associated methicillin-resistant Staphylococcus aureus has transitioned from USA400 to USA300 in most US communities. The explanation for this shift is unclear. We hypothesized that USA300 must be more pathogenic--specifically, that USA300 would have increased virulence when compared with USA400 in an animal model.

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