Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome | Zendy

Irving Nachamkin | Zendy; Sean V. Shadomy | Zendy; Anthony P. Moran | Zendy; Nancy J. Cox | Zendy; Collette Fitzgerald | Zendy; Huong Ung | Zendy; Adrian T. Corcoran | Zendy; John K. Iskander | Zendy; Lawrence B. Schonberger | Zendy; Robert T. Chen | Zendy

Open Access

Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome

Author(s) -

Irving Nachamkin,

Sean V. Shadomy,

Anthony P. Moran,

Nancy J. Cox,

Collette Fitzgerald,

Huong Ung,

Adrian T. Corcoran,

John K. Iskander,

Lawrence B. Schonberger,

Robert T. Chen

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/589624

Subject(s) - virology , campylobacter jejuni , antibody , hemagglutinin (influenza) , vaccination , influenza vaccine , biology , inactivated vaccine , virus , antigen , guillain barre syndrome , medicine , immunology , bacteria , genetics

Receipt of an A/NJ/1976/H1N1 "swine flu" vaccine in 1976, unlike receipt of influenza vaccines used in subsequent years, was strongly associated with the development of the neurologic disorder Guillain-Barré syndrome (GBS). Anti-ganglioside antibodies (e.g., anti-GM(1)) are associated with the development of GBS, and we hypothesized that the swine flu vaccine contained contaminating moieties (such as Campylobacter jejuni antigens that mimic human gangliosides or other vaccine components) that elicited an anti-GM(1) antibody response in susceptible recipients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research