The Evolution of Drug Resistance inMycobacterium tuberculosis:From a Mono–Rifampin‐Resistant Cluster into Increasingly Multidrug‐Resistant Variants in an HIV‐Seropositive Population | Zendy

Pablo Bifani | Zendy; Barun Mathema | Zendy; Natalia Kurepina | Zendy; Elena Shashkina | Zendy; Julie Bertout | Zendy; Anne Sophie Blanchis | Zendy; Soraya L. Moghazeh | Zendy; Jeffrey Driscoll | Zendy; Brigitte Gicquel | Zendy; Richard Frothingham | Zendy; Barry N. Kreiswirth | Zendy

Open Access

The Evolution of Drug Resistance inMycobacterium tuberculosis:From a Mono–Rifampin‐Resistant Cluster into Increasingly Multidrug‐Resistant Variants in an HIV‐Seropositive Population

Author(s) -

Pablo Bifani,

Barun Mathema,

Natalia Kurepina,

Elena Shashkina,

Julie Bertout,

Anne Sophie Blanchis,

Soraya L. Moghazeh,

Jeffrey Driscoll,

Brigitte Gicquel,

Richard Frothingham,

Barry N. Kreiswirth

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/588822

Subject(s) - mycobacterium tuberculosis , drug resistance , tuberculosis , microbiology and biotechnology , biology , multiple drug resistance , antibiotics , isoniazid , population , drug , antibiotic resistance , virology , rifampicin , genotype , genetics , medicine , gene , pharmacology , environmental health , pathology

We describe the genotypic and phenotypic characteristics of a mono-rifampin-resistant (RIF(R)) Mycobacterium tuberculosis strain cluster (designated AU-RIF(R)) and the acquisition of additional drug resistance. Drug susceptibility, sequences of regions that determine drug resistance, and basic clinical data were examined. A rare codon duplication (514(TTC)) in rpoB conferring high levels of RIF(R) (minimum inhibitory concentration of >256 microg/mL) in 29 isolates was identified. AU-RIF(R) strains developed secondary resistance to isoniazid and 7 resistance combinations to 6 different antibiotics. Patients infected with AU-RIF(R) strains were primarily immunocompromised. These data suggest that host factors, such as HIV status, may allow dissemination of mono-RIF(R) strains and facilitate the accumulation of additional drug resistance.

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