Emergence of Carbapenem Resistance inPseudomonas aeruginosaIsolates from a Patient with Cystic Fibrosis in the Absence of Carbapenem Therapy | Zendy

Daniel J. Wolter | Zendy; Dee Acquazzino | Zendy; Richard V. Goering | Zendy; Paul H. Sammut | Zendy; Noha Khalaf | Zendy; Nancy D. Hanson | Zendy

Open Access

Emergence of Carbapenem Resistance inPseudomonas aeruginosaIsolates from a Patient with Cystic Fibrosis in the Absence of Carbapenem Therapy

Author(s) -

Daniel J. Wolter,

Dee Acquazzino,

Richard V. Goering,

Paul H. Sammut,

Noha Khalaf,

Nancy D. Hanson

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/588484

Subject(s) - pseudomonas aeruginosa , cystic fibrosis , carbapenem , medicine , microbiology and biotechnology , drug resistance , antibiotics , bacteria , biology , genetics

The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

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