Common Nonsynonymous Polymorphisms in theNOD2Gene Are Associated with Resistance or Susceptibility to Tuberculosis Disease in African Americans | Zendy

Celest Austin | Zendy; Xin Ma | Zendy; Edward A. Graviss | Zendy

Open Access

Common Nonsynonymous Polymorphisms in theNOD2Gene Are Associated with Resistance or Susceptibility to Tuberculosis Disease in African Americans

Author(s) -

Celest Austin,

Xin Ma,

Edward A. Graviss

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/588384

Subject(s) - nonsynonymous substitution , tuberculosis , nod2 , mycobacterium tuberculosis , immunology , biology , innate immune system , disease , single nucleotide polymorphism , immune system , immunity , pattern recognition receptor , virology , gene , genetics , genotype , medicine , genome , pathology

Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms--Pro268Ser, Arg702Trp, and Ala725Gly--demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.

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