Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) inPlasmodium falciparumMalaria: Serum Levels of TIMP‐1 Are Associated with Disease Severity | Zendy

Anelia Dietmann | Zendy; Raimund Helbok | Zendy; Peter Lackner | Zendy; Saadou Issifou | Zendy; Bertrand Lell | Zendy; PierreBlaise Matsiegui | Zendy; Markus Reindl | Zendy; Erich Schmutzhard | Zendy; Peter G. Kremsner | Zendy

Open Access

Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) inPlasmodium falciparumMalaria: Serum Levels of TIMP‐1 Are Associated with Disease Severity

Author(s) -

Anelia Dietmann,

Raimund Helbok,

Peter Lackner,

Saadou Issifou,

Bertrand Lell,

PierreBlaise Matsiegui,

Markus Reindl,

Erich Schmutzhard,

Peter G. Kremsner

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/587943

Subject(s) - malaria , matrix metalloproteinase , plasmodium falciparum , pathogenesis , immunology , immune system , medicine , extracellular matrix , proteolytic enzymes , biology , enzyme , biochemistry , microbiology and biotechnology

Molecular mechanisms involved in the pathogenesis of severe malaria caused by Plasmodium falciparum are not fully understood. Matrix metalloproteinases (MMPs) are enzymes that proteolytically degrade both the extracellular matrix and nonmatrix substances with various functions in the modulation of immune response. The key inhibitors of MMPs are the tissue inhibitors of metalloproteinases (TIMPs).

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