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Molecular mechanisms involved in the pathogenesis of severe malaria caused by Plasmodium falciparum are not fully understood. Matrix metalloproteinases (MMPs) are enzymes that proteolytically degrade both the extracellular matrix and nonmatrix substances with various functions in the modulation of immune response. The key inhibitors of MMPs are the tissue inhibitors of metalloproteinases (TIMPs).

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) in<i>Plasmodium falciparum</i>Malaria: Serum Levels of TIMP‐1 Are Associated with Disease Severity

Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) inPlasmodium falciparumMalaria: Serum Levels of TIMP‐1 Are Associated with Disease Severity