The Impact of HIV Tropism on Decreases in CD4 Cell Count, Clinical Progression, and Subsequent Response to a First Antiretroviral Therapy Regimen | Zendy

Laura Waters | Zendy; Sundhiya Mandalia | Zendy; Paul Randell | Zendy; Adrian Wildfire | Zendy; Brian Gazzard | Zendy; Graeme Moyle | Zendy

Open Access

The Impact of HIV Tropism on Decreases in CD4 Cell Count, Clinical Progression, and Subsequent Response to a First Antiretroviral Therapy Regimen

Author(s) -

Laura Waters,

Sundhiya Mandalia,

Paul Randell,

Adrian Wildfire,

Brian Gazzard,

Graeme Moyle

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/587660

Subject(s) - tropism , cxcr4 , medicine , chemokine receptor , virology , lentivirus , regimen , virus , human immunodeficiency virus (hiv) , immunology , tissue tropism , co receptor , chemokine , receptor , cd4 t cell , viral disease , t cell , immune system

Human immunodeficiency virus (HIV) uses 2 distinct chemokine receptors, CCR5 (R5) or CXCR4 (X4), during entry. Viruses may be R5 tropic, X4 tropic, or dual/mixed (D/M) tropic. R5-tropic virus predominates at high CD4 cell counts, with the number of X4-tropic strains increasing as CD4 cell count decreases.

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