Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites? | Zendy

ShaoLing Zhang | Zendy; Sophie Hüe | Zendy; D. Sène | Zendy; A. Penfornis | Zendy; Solange BressonHadni | Zendy; B Kantelip | Zendy; Sophie CaillatZucman | Zendy; Dominique A. Vuitton | Zendy

Open Access

Expression of Major Histocompatibility Complex Class I Chain–Related Molecule A, NKG2D, and Transforming Growth Factor–β in the Liver of Humans with Alveolar Echinococcosis: New Actors in the Tolerance to Parasites?

Author(s) -

ShaoLing Zhang,

Sophie Hüe,

D. Sène,

A. Penfornis,

Solange BressonHadni,

B Kantelip,

Sophie CaillatZucman,

Dominique A. Vuitton

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/586709

Subject(s) - nkg2d , biology , immunology , transforming growth factor beta , major histocompatibility complex , immune system , pathology , transforming growth factor , cytotoxic t cell , microbiology and biotechnology , medicine , biochemistry , in vitro

Echinococcus multilocularis growth and persistent granuloma, which lead to the development of the severe parasitic disease alveolar echinococcosis (AE), might be caused by abnormal expression of stress-induced proteins, with subsequent abnormalities in T cell activation. Similar to its involvement in tumors, the NKG2D-major histocompatability complex class I chain-related molecules A and B (MICA/B) signaling system could be involved in host-parasite interactions; however, its involvement in helminthic diseases has never been studied.

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