Comprehensive Genetic and Epigenetic Analysis of Occult Hepatitis B from Liver Tissue Samples | Zendy

Perumal Vivekanandan | Zendy; Rajesh Kannangai | Zendy; Stuart C. Ray | Zendy; David L. Thomas | Zendy; Michael Torbenson | Zendy

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Comprehensive Genetic and Epigenetic Analysis of Occult Hepatitis B from Liver Tissue Samples

Author(s) -

Perumal Vivekanandan,

Rajesh Kannangai,

Stuart C. Ray,

David L. Thomas,

Michael Torbenson

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/529437

Subject(s) - hepatitis b virus , occult , virology , epigenetics , dna methylation , hepatitis b , biology , cpg site , medicine , virus , genetics , gene , pathology , gene expression , alternative medicine

Occult infection with hepatitis B virus (HBV) is a type of chronic HBV infection that is characterized by the absence of a detectable hepatitis B surface antigen in the blood and by very low levels of HBV DNA in the blood and liver. The mechanisms leading to occult HBV infection remain poorly understood but include possible genetic mutations and deletions. Recently, it has been shown that HBV has CpG islands that are methylated, raising the possibility that epigenetic changes may also be important.

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