High Sensitivity of Human Leukocyte Antigen–B*5701 as a Marker for Immunologically Confirmed Abacavir Hypersensitivity in White and Black Patients | Zendy

Michael S. Saag | Zendy; Rukmini Balu | Zendy; Elizabeth J. Phillips | Zendy; Philip S. Brachman | Zendy; Claudia Martorell | Zendy; William J. Burman | Zendy; Britt Stancil | Zendy; Michael Mosteller | Zendy; Cindy Brothers | Zendy; Paul Wannamaker | Zendy; Arlene R. Hughes | Zendy; Denise SutherlandPhillips | Zendy; S. Mallal | Zendy; Mark S. Shaefer | Zendy

Open Access

High Sensitivity of Human Leukocyte Antigen–B*5701 as a Marker for Immunologically Confirmed Abacavir Hypersensitivity in White and Black Patients

Author(s) -

Michael S. Saag,

Rukmini Balu,

Elizabeth J. Phillips,

Philip S. Brachman,

Claudia Martorell,

William J. Burman,

Britt Stancil,

Michael Mosteller,

Cindy Brothers,

Paul Wannamaker,

Arlene R. Hughes,

Denise SutherlandPhillips,

S. Mallal,

Mark S. Shaefer

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/529382

Subject(s) - abacavir , medicine , human leukocyte antigen , immunology , antigen , hepatitis b virus , virus , lamivudine

Although the human leukocyte antigen (HLA)-B*5701 is highly associated with a hypersensitivity reaction (HSR) to abacavir (ABC), variable sensitivities have been reported when clinical data alone have been used to define an ABC HSR. This study evaluated the sensitivity of detection of the HLA-B*5701 allele as a marker of ABC HSRs in both white and black patients, using skin patch testing to supplement clinical diagnosis.

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