HIV‐1 Variation before Seroconversion in Men Who Have Sex with Men: Analysis of Acute/Early HIV Infection in the Multicenter AIDS Cohort Study | Zendy

Geoffrey S. Gottlieb | Zendy; Laura Heath | Zendy; David C. Nickle | Zendy; Kim Wong | Zendy; Stephanie E. Leach | Zendy; Benjamin Meir Jacobs | Zendy; Surafel Gezahegne | Zendy; Angélique B. van ’t Wout | Zendy; Lisa P. Jacobson | Zendy; Joseph B. Margolick | Zendy; James I. Mullins | Zendy

Open Access

HIV‐1 Variation before Seroconversion in Men Who Have Sex with Men: Analysis of Acute/Early HIV Infection in the Multicenter AIDS Cohort Study

Author(s) -

Geoffrey S. Gottlieb,

Laura Heath,

David C. Nickle,

Kim Wong,

Stephanie E. Leach,

Benjamin Meir Jacobs,

Surafel Gezahegne,

Angélique B. van ’t Wout,

Lisa P. Jacobson,

Joseph B. Margolick,

James I. Mullins

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/529206

Subject(s) - multicenter aids cohort study , seroconversion , human immunodeficiency virus (hiv) , medicine , cohort , men who have sex with men , cohort study , multicenter study , sida , immunology , virology , demography , viral disease , syphilis , sociology , randomized controlled trial

Understanding the characteristics of human immunodeficiency virus (HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome (AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity (0.2%-5.6% [median, 0.86%]), V1-V2 loop length (58-93 aa), and potential N-linked glycosylation sites (n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research