Complement‐Dependent Synergistic Bactericidal Activity of Antibodies against Factor H–Binding Protein, a Sparsely Distributed Meningococcal Vaccine Antigen | Zendy

Jo Anne Welsch | Zendy; Sanjay Ram | Zendy; Oliver Koeberling | Zendy; Dan M. Granoff | Zendy

Open Access

Complement‐Dependent Synergistic Bactericidal Activity of Antibodies against Factor H–Binding Protein, a Sparsely Distributed Meningococcal Vaccine Antigen

Author(s) -

Jo Anne Welsch,

Sanjay Ram,

Oliver Koeberling,

Dan M. Granoff

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/528994

Subject(s) - antibody , antigen , meningococcal vaccine , complement system , factor h , complement (music) , microbiology and biotechnology , alternative complement pathway , neisseria meningitidis , complement factor i , complement factor b , plasma protein binding , chemistry , virology , biology , immunology , bacteria , biochemistry , immunization , genetics , complementation , phenotype , gene

Antibodies to factor H (fH)-binding protein (fHBP), a meningococcal vaccine antigen, activate classical complement pathway serum bactericidal activity (SBA) and block binding of the complement inhibitor fH.

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