Biofilm Formation Induces C3a Release and ProtectsStaphylococcus epidermidisfrom IgG and Complement Deposition and from Neutrophil‐Dependent Killing | Zendy

Sascha A. Kristian | Zendy; Timo A. Birkenstock | Zendy; Ursula Sauder | Zendy; Dietrich Mack | Zendy; Friedrich Götz | Zendy; Régine Landmann | Zendy

Open Access

Biofilm Formation Induces C3a Release and ProtectsStaphylococcus epidermidisfrom IgG and Complement Deposition and from Neutrophil‐Dependent Killing

Author(s) -

Sascha A. Kristian,

Timo A. Birkenstock,

Ursula Sauder,

Dietrich Mack,

Friedrich Götz,

Régine Landmann

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/528992

Subject(s) - staphylococcus epidermidis , microbiology and biotechnology , complement system , biofilm , virulence factor , virulence , antibody , pathogen , immunology , biology , staphylococcus aureus , chemistry , bacteria , biochemistry , gene , genetics

Biofilm formation is considered to be an important virulence factor of the opportunistic pathogen Staphylococcus epidermidis. We hypothesized that biofilm formation could interfere with the deposition of immunoglobulins and complement on the bacterial surface, leading to diminished activation of the complement system and protection from killing by human phagocytes.

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