Dobrava Virus RNA Load in Patients Who Have Hemorrhagic Fever with Renal Syndrome | Zendy

Ana Saksida | Zendy; Darja Duh | Zendy; Miša Korva | Zendy; Tatjana AvšičŽupanc | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Dobrava Virus RNA Load in Patients Who Have Hemorrhagic Fever with Renal Syndrome

Author(s) -

Ana Saksida,

Darja Duh,

Miša Korva,

Tatjana AvšičŽupanc

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/527485

Subject(s) - viremia , viral load , pathogenesis , virus , virology , reverse transcriptase , medicine , disease , hantavirus , real time polymerase chain reaction , immunology , rna , biology , gene , biochemistry

To asses the role of virus load in the pathogenesis of hemorrhagic fever with renal syndrome, the serum Dobrava virus RNA load in 46 patients was measured with a novel quantitative real-time reverse-transcriptase polymerase chain reaction assay and compared to the disease severity. The level of viremia, detected in 26 patients, ranged from 10(2)-10(8) copies/mL of serum. The patients with severe disease had, on average, higher viral RNA loads than patients with a milder course of disease (6.15 vs. 4.67 log(10) copies/mL; P = .053). These results suggest that the Dobrava virus load might be associated with the severity of disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research