Varicella‐Zoster Virus in the Saliva of Patients with Herpes Zoster | Zendy

Satish Mehta | Zendy; Stephen K. Tyring | Zendy; Donald H. Gilden | Zendy; Randall J. Cohrs | Zendy; Melanie J. Leal | Zendy; Victoria Castro | Zendy; Alan H. Feiveson | Zendy; C. Mark Ott | Zendy; Duane L. Pierson | Zendy

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Varicella‐Zoster Virus in the Saliva of Patients with Herpes Zoster

Author(s) -

Satish Mehta,

Stephen K. Tyring,

Donald H. Gilden,

Randall J. Cohrs,

Melanie J. Leal,

Victoria Castro,

Alan H. Feiveson,

C. Mark Ott,

Duane L. Pierson

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/527420

Subject(s) - varicella zoster virus , virology , saliva , medicine , chickenpox , virus

Fifty-four patients with herpes zoster were treated with valacyclovir. On treatment days 1, 8, and 15, pain was scored and saliva examined for varicella-zoster virus (VZV) DNA. VZV DNA was found in every patient the day treatment was started and later disappeared in 82%. There was a positive correlation between the presence of VZV DNA and pain and between VZV DNA copy number and pain (P <.0005). VZV DNA was present in 1 patient before rash and in 4 after pain resolved and was not present in any of 6 subjects with chronic pain or in 14 healthy subjects. Analysis of human saliva has potential usefulness in the diagnosis of neurological disease produced by VZV without rash.

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