Vaccines for the Unvaccinated: Protecting the Herd | Zendy

David S. Stephens | Zendy

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Vaccines for the Unvaccinated: Protecting the Herd

Author(s) -

David S. Stephens

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/527402

Subject(s) - carriage , meningococcal disease , neisseria meningitidis , medicine , meningococcal vaccine , virology , serotype , herd immunity , conjugate vaccine , vaccination , microbiology and biotechnology , immunology , biology , immunization , antibody , bacteria , pathology , genetics

andcharacterizedbygenotypingandphenotyping. A significant and specific reduction in the prevalence of serogroup C meningococcal carriage was noted that lasted at least during the 2 years of the study, without evidence of new meningococcal serogroup replacement. Vaccine efficacy against serogroup C carriage was at least 75%, with a high impact on the virulent clonal complex of serogroup C meningococci associated with invasive meningococcal disease. The decreases in the prevalence of carriage correlated with reductions in serogroup C meningococcal disease in unvaccinated individuals; at least 50% of the effectiveness of the meningococcal serogroup C conjugate vac

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