1,3- -D-Glucan Antigenemia for Early Diagnosis of Invasive Fungal Infections in Neutropenic Patients with Acute Leukemia | Zendy

Laurence Senn | Zendy; James O. Robinson | Zendy; Sabine Schmidt | Zendy; M. Knaup | Zendy; N. Asahi | Zendy; Shinji Satomura | Zendy; S. Matsuura | Zendy; B Duvoisin | Zendy; J. Bille | Zendy; Thierry Calandra | Zendy; Oscar Marchetti | Zendy

Open Access

1,3- -D-Glucan Antigenemia for Early Diagnosis of Invasive Fungal Infections in Neutropenic Patients with Acute Leukemia

Author(s) -

Laurence Senn,

James O. Robinson,

Sabine Schmidt,

M. Knaup,

N. Asahi,

Shinji Satomura,

S. Matsuura,

B Duvoisin,

J. Bille,

Thierry Calandra,

Oscar Marchetti

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/527382

Subject(s) - medicine , acute leukemia , neutropenia , leukemia , microbiology and biotechnology , immunology , intensive care medicine , biology , chemotherapy

Invasive fungal infections (IFIs) are life-threatening complications in neutropenic patients with hematological malignancies. Because early diagnosis of IFI is difficult, new noninvasive, culture-independent diagnostic tools are needed to improve clinical management. Recent studies have reported that detection of 1,3-beta-D-glucan (BG) antigenemia may be useful for diagnosis of IFI. The aim of the present prospective study was to evaluate the usefulness of monitoring BG in patients undergoing chemotherapy for acute leukemia.

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