Open AccessBone Marrow Cell Therapy Ameliorates and Reverses Chagasic Cardiomyopathy in a Mouse Model
Author(s) -
Regina Coeli dos Santos Goldenberg,
Linda A. Jelicks,
Antonio F. Fortes,
Louis M. Weiss,
Leonardo Lima Rocha,
Dazhi Zhao,
Antônio Carlos Campos de Carvalho,
David C. Spray,
Herbert B. Tanowitz
Publication year - 2008
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/526793
Subject(s) - medicine , bone marrow , cardiomyopathy , chagas disease , heart failure , trypanosoma cruzi , inflammation , fibrosis , pathology , peripheral blood mononuclear cell , transplantation , cardiology , biology , world wide web , parasite hosting , biochemistry , computer science , in vitro
Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance imaging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model.
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