Acute Cytomegalovirus Colitis Presenting during Primary HIV Infection: an Unusual Case of an Immune Reconstitution Inflammatory Syndrom | Zendy

Ulrich von Both | Zendy; R. Laffer | Zendy; Christina Grube | Zendy; Walter Bossart | Zendy; Ariana Gaspert | Zendy; H. F. Gu nthard | Zendy

Open Access

Acute Cytomegalovirus Colitis Presenting during Primary HIV Infection: an Unusual Case of an Immune Reconstitution Inflammatory Syndrom

Author(s) -

Ulrich von Both,

R. Laffer,

Christina Grube,

Walter Bossart,

Ariana Gaspert,

H. F. Gu nthard

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/526783

Subject(s) - medicine , immunosuppression , immunology , cytomegalovirus , immune reconstitution inflammatory syndrome , colitis , perforation , immune system , bowel perforation , virology , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , viral disease , herpesviridae , complication , punching , materials science , metallurgy

Severe ulcerous cytomegalovirus pancolitis developed during primary human immunodeficiency virus (HIV) infection in a patient who underwent early combination antiretroviral treatment. This massive inflammatory process led to acute colon perforation. Serological testing demonstrated cytomegalovirus reactivation. Severe immunosuppression caused by primary HIV infection resulted in cytomegalovirus colitis, and initiation of early combination antiretroviral therapy triggered an immune reconstitution inflammatory syndrome potentially leading to colonic perforation.

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