Polymorphisms in Toll‐Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis | Zendy

Agostinho Carvalho | Zendy; Alessandro C. Pasqualotto | Zendy; Lucia Pitzurra | Zendy; Luigina Romani | Zendy; David W. Denning | Zendy; Fernando Rodrigues | Zendy

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Polymorphisms in Toll‐Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis

Author(s) -

Agostinho Carvalho,

Alessandro C. Pasqualotto,

Lucia Pitzurra,

Luigina Romani,

David W. Denning,

Fernando Rodrigues

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/526500

Subject(s) - immunology , aspergillosis , allergic bronchopulmonary aspergillosis , aspergillus fumigatus , tlr9 , innate immune system , pathogenesis , tlr2 , toll like receptor , allele , biology , tlr4 , odds ratio , immunity , gene , medicine , immune system , genetics , pathology , immunoglobulin e , antibody , gene expression , dna methylation

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

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