Open AccessHuman Cytomegalovirus (HCMV) DNAemia in the Mother at Amniocentesis as a Risk Factor for Iatrogenic HCMV Infection of the Fetus
Author(s) -
Maria Grazia Revello,
Milena Furione,
Maurizio Zavattoni,
Beatrice Tassis,
Umberto Nicolini,
Elisa Fabbri,
Giuseppe Gerna
Publication year - 2008
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/526499
Subject(s) - amniocentesis , human cytomegalovirus , fetus , medicine , cytomegalovirus , obstetrics , pregnancy , prenatal diagnosis , transmission (telecommunications) , risk factor , virology , immunology , herpesviridae , viral disease , pathology , virus , biology , genetics , electrical engineering , engineering
To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 were DNAemia-negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.
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