S-Adenosylmethionine Levels in the Diagnosis of Pneumocystis carinii Pneumonia in Patients with HIV Infection | Zendy

Michael Skelly | Zendy; Robert S. Holzman | Zendy; Salim Merali | Zendy

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S-Adenosylmethionine Levels in the Diagnosis of Pneumocystis carinii Pneumonia in Patients with HIV Infection

Author(s) -

Michael Skelly,

Robert S. Holzman,

Salim Merali

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/525854

Subject(s) - pneumocystis carinii , pneumonia , medicine , human immunodeficiency virus (hiv) , polyamine , metabolic activity , methylation , immunology , microbiology and biotechnology , pneumocystis jirovecii , biology , biochemistry , physiology , gene

S-adenosylmethionine (AdoMet) is a key molecule involved in methylation reactions and polyamine synthesis. Pneumocystis carinii are unable to synthesize this molecule and have been shown to scavenge this metabolic intermediate from the plasma of rats during active infection. A prior study involving humans strongly suggested that low levels of plasma AdoMet are sensitive and specific indicators of acute infection.

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