Persistence of Occult Hepatitis B after Removal of the Hepatitis B Virus–Infected Liver | Zendy

Sandra Ciesek | Zendy; Fabian Helfritz | Zendy; Ulrich Lehmann | Zendy; Thomas Becker | Zendy; Christian P. Strassburg | Zendy; Michael Neipp | Zendy; A. Ciner | Zendy; P. Fytili | Zendy; Hans L. Tillmann | Zendy; Michael P. Manns | Zendy; Heiner Wedemeyer | Zendy

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Persistence of Occult Hepatitis B after Removal of the Hepatitis B Virus–Infected Liver

Author(s) -

Sandra Ciesek,

Fabian Helfritz,

Ulrich Lehmann,

Thomas Becker,

Christian P. Strassburg,

Michael Neipp,

A. Ciner,

P. Fytili,

Hans L. Tillmann,

Michael P. Manns,

Heiner Wedemeyer

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/525286

Subject(s) - hbcag , hbsag , medicine , hepatitis b virus , occult , liver transplantation , virology , hepatitis b , immunology , hepadnaviridae , persistence (discontinuity) , hepatitis , transplantation , virus , pathology , alternative medicine , geotechnical engineering , engineering

Occult hepatitis B is defined as the persistence of hepatitis B virus (HBV) DNA in persons without HBV surface antigen (HBsAg). The primary site for HBV persistence in persons with occult hepatitis B is considered to be the liver. We provide virological and immunological evidence for long-term persistence of HBV, even after removal of the infected liver, in 25 consecutive, randomly selected liver transplant recipients who tested positive for anti-HBV core antigen (anti-HBcAg) and negative for HBsAg at the time of transplantation. Furthermore, in a cohort of 101 anti-HBcAg-positive/HBsAg-negative patients, 2 showed clinical HBV reactivation after transplantation. Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting.

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