Dynamics of Total, Linear Nonintegrated, and Integrated HIV‐1 DNA In Vivo and In Vitro | Zendy

Kersten K. Koelsch | Zendy; Lin Liu | Zendy; Richard Haubrich | Zendy; Susanne May | Zendy; Diane V. Havlir | Zendy; Huldrych F. Günthard | Zendy; Caroline Ignacio | Zendy; Paula CamposSoto | Zendy; Susan J. Little | Zendy; Robert W. Shafer | Zendy; Gregory K. Robbins | Zendy; Richard T. D’Aquila | Zendy; Yuji Kawano | Zendy; K K Young | Zendy; Phillip Dao | Zendy; Celsa A. Spina | Zendy; Douglas D. Richman | Zendy; Joseph K. Wong | Zendy

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Dynamics of Total, Linear Nonintegrated, and Integrated HIV‐1 DNA In Vivo and In Vitro

Author(s) -

Kersten K. Koelsch,

Lin Liu,

Richard Haubrich,

Susanne May,

Diane V. Havlir,

Huldrych F. Günthard,

Caroline Ignacio,

Paula CamposSoto,

Susan J. Little,

Robert W. Shafer,

Gregory K. Robbins,

Richard T. D’Aquila,

Yuji Kawano,

K K Young,

Phillip Dao,

Celsa A. Spina,

Douglas D. Richman,

Joseph K. Wong

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/525283

Subject(s) - dna , biology , peripheral blood mononuclear cell , virology , virus , in vitro , in vivo , immunology , genetics

In patients infected with human immunodeficiency virus type 1 (HIV-1), HIV-1 DNA persists during highly active antiretroviral treatment, reflecting long-lived cellular reservoirs of HIV-1. Recent studies report an association between HIV-1 DNA levels, disease progression, and treatment outcome. However, HIV-1 DNA exists as distinct molecular forms that are not distinguished by conventional assays.

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