Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea | Zendy

Ju Young Chang | Zendy; Dionysios A. Antonopoulos | Zendy; Apoorv Kalra | Zendy; Adriano R. Tonelli | Zendy; Walid Khalife | Zendy; Thomas M. Schmidt | Zendy; Vincent B. Young | Zendy

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Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea

Author(s) -

Ju Young Chang,

Dionysios A. Antonopoulos,

Apoorv Kalra,

Adriano R. Tonelli,

Walid Khalife,

Thomas M. Schmidt,

Vincent B. Young

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/525047

Subject(s) - diarrhea , microbiome , feces , clostridium difficile , biology , microbiology and biotechnology , clostridium , colonization , pathogen , phylogenetic diversity , antibiotics , bacteria , phylogenetic tree , medicine , bioinformatics , gene , genetics

Antibiotic-associated diarrhea due to Clostridium difficile (CDAD) is thought to reflect colonization of a disrupted microbial community by the pathogen. We profiled the fecal microbiota of patients with CDAD (both initial and recurrent episodes) by culture-independent phylogenetic analysis of 16S rRNA-encoding gene sequences. Compared with those from control subjects and patients with an initial episode, the fecal communities in patients with recurrent CDAD were highly variable in bacterial composition and were characterized by markedly decreased diversity. Preservation and restoration of the microbial diversity could represent novel strategies for prevention and treatment of recurrent CDAD, which is often recalcitrant to existing therapies.

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