Role Played by Toll‐Like Receptors 2 and 4 in Lipoteichoic Acid–Induced Lung Inflammation and Coagulation | Zendy

Mark C. Dessing | Zendy; Marcel Schouten | Zendy; Christian Draing | Zendy; Marcel Levi | Zendy; Sonja von Aulock | Zendy; Tom van der Poll | Zendy

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Role Played by Toll‐Like Receptors 2 and 4 in Lipoteichoic Acid–Induced Lung Inflammation and Coagulation

Author(s) -

Mark C. Dessing,

Marcel Schouten,

Christian Draing,

Marcel Levi,

Sonja von Aulock,

Tom van der Poll

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524873

Subject(s) - lipoteichoic acid , tlr2 , tlr4 , toll like receptor , cd14 , proinflammatory cytokine , streptococcus pneumoniae , inflammation , microbiology and biotechnology , in vivo , immunology , streptococcus pyogenes , coagulation , receptor , immune system , innate immune system , biology , chemistry , medicine , antibiotics , biochemistry , staphylococcus aureus , bacteria , genetics

The cell wall of Streptococcus pneumoniae consists of lipoteichoic acid (LTA), which is released when pneumococci are killed by either the host immune system or antibiotic treatment. Release of excessive amounts of LTA has been implicated in the toxic sequelae of severe gram-positive infection by virtue of its proinflammatory properties. Several in vitro studies have shown that LTA is recognized by Toll-like receptor (TLR) 2 and CD14. Our objective here was to investigate the inflammatory properties of S. pneumoniae LTA in vivo and the role played by TLR2, TLR4, and CD14 therein.

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