Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation | Zendy

Ravi Jhaveri | Zendy; John G. McHutchison | Zendy; Keyur Patel | Zendy; Qiang Guan | Zendy; Anna Mae Diehl | Zendy

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Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation

Author(s) -

Ravi Jhaveri,

John G. McHutchison,

Keyur Patel,

Qiang Guan,

Anna Mae Diehl

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524846

Subject(s) - genotype , intracellular , virology , hepatitis c virus , virus , biology , hepacivirus , flaviviridae , gene , genetics

Steatosis is a common histological finding and a poor prognostic indicator in patients with hepatitis C virus (HCV) infection. In HCV genotype 3-infected patients, the etiology of steatosis appears to be closely correlated with unknown viral factors that increase intracellular lipid levels. We hypothesize that specific sequence polymorphisms in HCV genotype 3 core protein may be associated with hepatic intracellular lipid accumulation.

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