Pharmacologic Augmentation of Hypoxia‐Inducible Factor–1α with Mimosine Boosts the Bactericidal Capacity of Phagocytes | Zendy

Annelies S. Zinkernagel | Zendy; Carole Peyssonnaux | Zendy; Randall S. Johnson | Zendy; Victor Nizet | Zendy

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Pharmacologic Augmentation of Hypoxia‐Inducible Factor–1α with Mimosine Boosts the Bactericidal Capacity of Phagocytes

Author(s) -

Annelies S. Zinkernagel,

Carole Peyssonnaux,

Randall S. Johnson,

Victor Nizet

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524843

Subject(s) - staphylococcus aureus , phagocytosis , innate immune system , microbiology and biotechnology , phagocyte , immune system , biology , pathogen , immunology , hypoxia (environmental) , hypoxia inducible factors , bacteria , chemistry , biochemistry , oxygen , genetics , organic chemistry , gene

Hypoxia-inducible factor (HIF)-1alpha is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1alpha agonist mimosine can boost the capacity of human phagocytes and whole blood to kill the leading pathogen Staphylococcus aureus in a dose-dependent fashion and reduce the lesion size in a murine model of S. aureus skin infection. This provides the first proof of principle for a novel approach to the treatment of bacterial infection by pharmacologically augmenting the host phagocytic function.

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