Genetic Deficiency of Chemokine Receptor CCR5 Is a Strong Risk Factor for Symptomatic West Nile Virus Infection: A Meta‐Analysis of 4 Cohorts in the US Epidemic | Zendy

Jean K. Lim | Zendy; Christine Y. Louie | Zendy; Carol Glaser | Zendy; Cynthia Jean | Zendy; Bernard D. Johnson | Zendy; Hope L. Johnson | Zendy; David H. McDermott | Zendy; Philip M. Murphy | Zendy

Open Access

Genetic Deficiency of Chemokine Receptor CCR5 Is a Strong Risk Factor for Symptomatic West Nile Virus Infection: A Meta‐Analysis of 4 Cohorts in the US Epidemic

Author(s) -

Jean K. Lim,

Christine Y. Louie,

Carol Glaser,

Cynthia Jean,

Bernard D. Johnson,

Hope L. Johnson,

David H. McDermott,

Philip M. Murphy

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524691

Subject(s) - odds ratio , chemokine receptor ccr5 , virology , confidence interval , risk factor , medicine , virus , immunology , west nile virus , biology , chemokine receptor , chemokine , receptor

West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.

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