Haemophilus influenzae Type b Vaccine Failure in Children Is Associated with Inadequate Production of High-Quality Antibody | Zendy

Yeh Chen Lee | Zendy; Dominic F. Kelly | Zendy; LyMee Yu | Zendy; Mary Slack | Zendy; Robert Booy | Zendy; Paul T. Heath | Zendy; C.-A. Siegrist | Zendy; Richard Moxon | Zendy; A J Pollard | Zendy

Open Access

Haemophilus influenzae Type b Vaccine Failure in Children Is Associated with Inadequate Production of High-Quality Antibody

Author(s) -

Yeh Chen Lee,

Dominic F. Kelly,

LyMee Yu,

Mary Slack,

Robert Booy,

Paul T. Heath,

C.-A. Siegrist,

Richard Moxon,

A J Pollard

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/524668

Subject(s) - medicine , avidity , vaccine failure , hib vaccine , antibody , vaccination , haemophilus influenzae , immunology , immunogenicity , conjugate vaccine , pediatrics , immunization , microbiology and biotechnology , biology , antibiotics

Despite the excellent immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines, breakthrough cases of Hib disease still affect a small proportion of vaccinated children in the United Kingdom. We performed a retrospective study to compare the avidity of antibody directed against the Hib polysaccharide capsule (PRP) in children who experienced Hib vaccine failure in the United Kingdom among 3 historical cohorts and with age-matched healthy control subjects.

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