Variation in HLA Class I Antigen‐Processing Genes and Susceptibility to Human Papillomavirus Type 16–Associated Cervical Cancer | Zendy

Alina Deshpande | Zendy; Cosette M. Wheeler | Zendy; William C. Hunt | Zendy; Cheri L. Peyton | Zendy; Paul S. White | Zendy; Yolanda E. Valdez | Zendy; John P. Nolan | Zendy

Open Access

Variation in HLA Class I Antigen‐Processing Genes and Susceptibility to Human Papillomavirus Type 16–Associated Cervical Cancer

Author(s) -

Alina Deshpande,

Cosette M. Wheeler,

William C. Hunt,

Cheri L. Peyton,

Paul S. White,

Yolanda E. Valdez,

John P. Nolan

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524300

Subject(s) - human leukocyte antigen , cervical cancer , single nucleotide polymorphism , genotype , biology , haplotype , genotyping , immunology , context (archaeology) , cancer , antigen , genetics , gene , paleontology

Persistent infection with human papillomavirus type 16 (HPV16) is a primary etiological factor for the development of cervical cancer. Genes involved in antigen processing influence both the repertoire of antigens presented by HPV16-infected cells and the nature of HPV16-specific immune responses. Genetic variation in these genes may affect protein structure and function and, consequently, the ability of an individual to clear HPV infection.

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