Chronic Hepatitis B in Italy: New Features of an Old Disease--Approaching the Universal Prevalence of Hepatitis B e Antigen--Negative Cases and the Eradication of Hepatitis D Infection | Zendy

Evangelista Sagnelli | Zendy; Tommaso Stroffolini | Zendy; Andrea Mele | Zendy; Michele Imparato | Zendy; P.L. Almasio | Zendy

Open Access

Chronic Hepatitis B in Italy: New Features of an Old Disease--Approaching the Universal Prevalence of Hepatitis B e Antigen--Negative Cases and the Eradication of Hepatitis D Infection

Author(s) -

Evangelista Sagnelli,

Tommaso Stroffolini,

Andrea Mele,

Michele Imparato,

P.L. Almasio

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/524074

Subject(s) - medicine , cirrhosis , hepatitis , hepatitis c virus , liver disease , hepatitis b , virology , virus , hepatitis b virus , viral disease , hepatitis c , immunology , gastroenterology

We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis.

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