Localization of Multiple Quantitative Trait Loci Influencing Susceptibility to Infection withAscaris lumbricoides | Zendy

Sarah WilliamsBlangero | Zendy; John L. VandeBerg | Zendy; Janardan Subedi | Zendy; Bharat Jha | Zendy; Rodrigo CorrêaOliveira | Zendy; John Blangero | Zendy

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Localization of Multiple Quantitative Trait Loci Influencing Susceptibility to Infection withAscaris lumbricoides

Author(s) -

Sarah WilliamsBlangero,

John L. VandeBerg,

Janardan Subedi,

Bharat Jha,

Rodrigo CorrêaOliveira,

John Blangero

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/524060

Subject(s) - quantitative trait locus , ascaris lumbricoides , biology , genetics , genetic linkage , linkage (software) , population , ascaris , chromosome , genome , genome scan , centimorgan , gene , gene mapping , allele , helminths , microsatellite , zoology , medicine , environmental health

A linkage-based genome scan of 1,258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013, 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.

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