Effect of Highly Active Antiretroviral Therapy on Viral Burden in the Lungs of HIV‐Infected Subjects | Zendy

Homer L. Twigg | Zendy; Michael D. Weiden | Zendy; Fred Valentine | Zendy; Carol SchnizleinBick | Zendy; Roland L. Bassett | Zendy; Lu Zheng | Zendy; Joseph Wheat | Zendy; Richard B. Day | Zendy; Helen Rominger | Zendy; Ronald G. Collman | Zendy; Lawrence Fox | Zendy; Barbara Brizz | Zendy; Joan Dragavon | Zendy; Robert W. Coombs | Zendy; R. Pat Bucy | Zendy

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Effect of Highly Active Antiretroviral Therapy on Viral Burden in the Lungs of HIV‐Infected Subjects

Author(s) -

Homer L. Twigg,

Michael D. Weiden,

Fred Valentine,

Carol SchnizleinBick,

Roland L. Bassett,

Lu Zheng,

Joseph Wheat,

Richard B. Day,

Helen Rominger,

Ronald G. Collman,

Lawrence Fox,

Barbara Brizz,

Joan Dragavon,

Robert W. Coombs,

R. Pat Bucy

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/523766

Subject(s) - bronchoalveolar lavage , viremia , viral load , medicine , peripheral blood mononuclear cell , immunology , cd8 , lung , lymphocyte , lentivirus , virus , viral disease , virology , immune system , biology , in vitro , biochemistry

Human immunodeficiency virus (HIV) is readily detectable in the lungs of infected subjects and leads to an accumulation of CD8(+) lymphocytes in the alveolar space. Although highly active antiretroviral therapy (HAART) is effective in reducing viremia, less is known about its effect on tissue compartments. The AIDS Clinical Trials Group Protocol 723 Team evaluated the effect of HAART on lung viral load and cellular constituents.

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