Polymorphisms in the Gene for Lymphotoxin‐α Predispose to Chronic Chagas Cardiomyopathy | Zendy

Rajendranath Ramasawmy | Zendy; Kellen C. Faé | Zendy; Edécio CunhaNeto | Zendy; Natalie Müller | Zendy; Vanessa L. Cavalcanti | Zendy; Raquel Conceição Ferreira | Zendy; Sandra A. Drigo | Zendy; Bárbara Maria Ianni | Zendy; Charles Mady | Zendy; Anna Carla Goldberg | Zendy; Jorge Kalil | Zendy

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Polymorphisms in the Gene for Lymphotoxin‐α Predispose to Chronic Chagas Cardiomyopathy

Author(s) -

Rajendranath Ramasawmy,

Kellen C. Faé,

Edécio CunhaNeto,

Natalie Müller,

Vanessa L. Cavalcanti,

Raquel Conceição Ferreira,

Sandra A. Drigo,

Bárbara Maria Ianni,

Charles Mady,

Anna Carla Goldberg,

Jorge Kalil

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/523653

Subject(s) - lymphotoxin , chagas disease , cardiomyopathy , immunology , lymphotoxin alpha , gene , medicine , biology , genetics , heart failure , immune system

Chagas disease, caused by Trypanosoma cruzi infection, displays clinical heterogeneity and may be attributable to differential genetic susceptibility. Chronic Chagas cardiomyopathy (CCC) develops only in a subset of T. cruzi-infected individuals and may lead to heart failure that has a worse clinical course and that leads to reduced life expectancy, compared with heart failure of other etiologies. Proinflammatory cytokines play a key role in the development of CCC. Clinical, genetic, and epidemiological studies have linked lymphotoxin-alpha (LTA), a proinflammatory cytokine, to coronary artery disease and myocardial infarction.

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