Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations | Zendy

Tomoyuki Sakamoto | Zendy; Yasuhito Tanaka | Zendy; Josephine Simonetti | Zendy; Carla Osiowy | Zendy; Malene Landbo Børresen | Zendy; Anders Koch | Zendy; Fuat Kurbanov | Zendy; Masaya Sugiyama | Zendy; Gerald Y. Minuk | Zendy; Brian J. McMahon | Zendy; Takashi Joh | Zendy; Masashi Mizokami | Zendy

Open Access

Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations

Author(s) -

Tomoyuki Sakamoto,

Yasuhito Tanaka,

Josephine Simonetti,

Carla Osiowy,

Malene Landbo Børresen,

Anders Koch,

Fuat Kurbanov,

Masaya Sugiyama,

Gerald Y. Minuk,

Brian J. McMahon,

Takashi Joh,

Masashi Mizokami

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/523111

Subject(s) - hepatitis b virus , genotype , phylogenetic tree , virology , biology , recombinant dna , recombination , hepatitis b , virus , orthohepadnavirus , genetics , hepadnaviridae , gene

Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.

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