Randomized Comparison of Amodiaquine plus Sulfadoxine-Pyrimethamine, Artemether-Lumefantrine, and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Burkina Faso | Zendy

Issaka Zongo | Zendy; Grant Dorsey | Zendy; Noël Rouamba | Zendy; C. Dokomajilar | Zendy; Y. Séré | Zendy; Philip J. Rosenthal | Zendy; JeanBosco Ouédraogo | Zendy

Open Access

Randomized Comparison of Amodiaquine plus Sulfadoxine-Pyrimethamine, Artemether-Lumefantrine, and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Burkina Faso

Author(s) -

Issaka Zongo,

Grant Dorsey,

Noël Rouamba,

C. Dokomajilar,

Y. Séré,

Philip J. Rosenthal,

JeanBosco Ouédraogo

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/522985

Subject(s) - medicine , amodiaquine , artemether/lumefantrine , lumefantrine , sulfadoxine/pyrimethamine , piperaquine , artemether , regimen , malaria , sulfadoxine , population , plasmodium falciparum , artemisinin , pyrimethamine , immunology , environmental health

Combination antimalarial therapy is advocated to improve treatment efficacy and limit selection of drug-resistant parasites. We compared the efficacies of 3 combination regimens in Bobo-Dioulasso, Burkina Faso: amodiaquine plus sulfadoxine-pyrimethamine, which was recently shown to be highly efficacious at this site; artemether-lumefantrine, the new national first-line antimalarial regimen; and dihydroartemisinin-piperaquine (DP), a newer regimen.

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