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Adenoviruses (Ads) cause continuous outbreaks of acute respiratory disease (ARD) in US military training facilities. In 1996, the loss of vaccines targeting the dominant recruit-associated serotypes precipitated the reemergence of Ads in these populations. Between 1999 and 2002, serotype 4 accounted for &gt;95% of Ads isolated from recruits and for &gt;50% of ARD cases in training facilities (15,000 cases/year).

Abrupt Emergence of Diverse Species B Adenoviruses at US Military Recruit Training Centers