Identification of Human T Cell Targets Recognized duringChlamydia trachomatisGenital Infection | Zendy

Anja Weinreich Olsen | Zendy; Frank Follmann | Zendy; Peter Højrup | Zendy; Robert Leah | Zendy; Carsten Sand | Zendy; Peter Andersen | Zendy; Michael Theisen | Zendy

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Identification of Human T Cell Targets Recognized duringChlamydia trachomatisGenital Infection

Author(s) -

Anja Weinreich Olsen,

Frank Follmann,

Peter Højrup,

Robert Leah,

Carsten Sand,

Peter Andersen,

Michael Theisen

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/522524

Subject(s) - chlamydia trachomatis , identification (biology) , chlamydia , chlamydia trachomatis infection , chlamydiaceae , chlamydiales , virology , sex organ , biology , sexually transmitted disease , chlamydial infection , immunology , human immunodeficiency virus (hiv) , genetics , botany , syphilis

The specificity of the human T cell response to Chlamydia trachomatis was investigated by stimulating lymphocytes from 16 case patients with urogenital infection by use of a size-fractionated serovar D lysate. Considerable heterogeneity was found among case patients, and multiple protein fractions were recognized in each specimen. Mass spectrometry analysis of the 30-42-kDa T cell-stimulating region identified 10 C. trachomatis proteins. Of these, CT583, CT603, and CT610 were identified as strong antigens that induced significantly higher levels of IFN- gamma secretion in PBMCs from case patients, compared with PBMCs from control donors. All 3 proteins were recognized in specimens from case patients infected with serovars D-F, the most prevalent serovars. McDonald-Kreitman and Tajima's D tests involving clinical isolates from the same samples showed evidence for frequency-dependent selection on ct583. We predict that CT583 is a target of acquired protective immune responses in humans.

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