Detection of Toxigenic Clostridium difficile in Stool Samples by Real-Time Polymerase Chain Reaction for the Diagnosis of C. difficile-Associated Diarrhea | Zendy

Lance R. Peterson | Zendy; Richard Manson | Zendy; Suzanne M. Paule | Zendy; Donna M. Hacek | Zendy; Ari Robicsek | Zendy; Richard B. Thomson | Zendy; Karen L. Kaul | Zendy

Open Access

Detection of Toxigenic Clostridium difficile in Stool Samples by Real-Time Polymerase Chain Reaction for the Diagnosis of C. difficile-Associated Diarrhea

Author(s) -

Lance R. Peterson,

Richard Manson,

Suzanne M. Paule,

Donna M. Hacek,

Ari Robicsek,

Richard B. Thomson,

Karen L. Kaul

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/522185

Subject(s) - medicine , diarrhea , immunoassay , polymerase chain reaction , clostridiaceae , clostridium difficile , positive predicative value , microbiology and biotechnology , real time polymerase chain reaction , gold standard (test) , feces , gastroenterology , predictive value , immunology , biology , antibiotics , antibody , toxin , biochemistry , gene

Clostridium difficile-associated diarrhea (CDAD) is the major cause of health care-associated infectious diarrhea. Current laboratory testing lacks a single assay that is sensitive, specific, and rapid. The purpose of this work was to design and validate a sensitive and specific real-time polymerase chain reaction (PCR) diagnostic test for CDAD.

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