Successful Efavirenz Dose Reduction in HIV Type 1-Infected Individuals with Cytochrome P450 2B6 *6 and *26 | Zendy

Hiroyuki Gatanaga | Zendy; Tsunefusa Hayashida | Zendy; K. Tsuchiya | Zendy; Masanori Yoshino | Zendy; Taishi Kuwahara | Zendy; Hiroki Tsukada | Zendy; Katsuya Fujimoto | Zendy; Ikuyo Sato | Zendy; Mikio Ueda | Zendy; Masahide Horiba | Zendy; Motohiro Hamaguchi | Zendy; Masahiro Yamamoto | Zendy; Noboru Takata | Zendy; A. Kimura | Zendy; Takayoshi Koike | Zendy; Fumitake Gejyo | Zendy; Shuzo Matsushita | Zendy; T Shirasaka | Zendy; Sadao Kimura | Zendy; Shinichi Oka | Zendy

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Successful Efavirenz Dose Reduction in HIV Type 1-Infected Individuals with Cytochrome P450 2B6 *6 and *26

Author(s) -

Hiroyuki Gatanaga,

Tsunefusa Hayashida,

K. Tsuchiya,

Masanori Yoshino,

Taishi Kuwahara,

Hiroki Tsukada,

Katsuya Fujimoto,

Ikuyo Sato,

Mikio Ueda,

Masahide Horiba,

Motohiro Hamaguchi,

Masahiro Yamamoto,

Noboru Takata,

A. Kimura,

Takayoshi Koike,

Fumitake Gejyo,

Shuzo Matsushita,

T Shirasaka,

Sadao Kimura,

Shinichi Oka

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/522175

Subject(s) - efavirenz , cyp2b6 , medicine , pharmacology , pharmacokinetics , gastroenterology , virology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , cytochrome p450 , metabolism , cyp3a4

Efavirenz (EFV) is metabolized primarily by cytochrome P450 2B6 (CYP2B6), and high plasma concentrations of the drug are associated with a G-->T polymorphism at position 516 (516G-->T) of CYP2B6 and frequent central nervous system (CNS)-related side effects. Here, we tested the feasibility of genotype-based dose reduction of EFV.

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