Genomewide Linkage Analysis of the Granulomatous Mitsuda Reaction Implicates Chromosomal Regions 2q35 and 17q21 | Zendy

Brigitte Ranque | Zendy; Andrea Alter | Zendy; Marcelo Távora Mira | Zendy; Nguyen Van Thuc | Zendy; Vu Hong Thai | Zendy; Nguyễn Thu Hương | Zendy; Nguyen Ngoc Ba | Zendy; Pham Xuan Khoa | Zendy; Erwin Schurr | Zendy; Laurent Abel | Zendy; Alexandre Alcaïs | Zendy

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Genomewide Linkage Analysis of the Granulomatous Mitsuda Reaction Implicates Chromosomal Regions 2q35 and 17q21

Author(s) -

Brigitte Ranque,

Andrea Alter,

Marcelo Távora Mira,

Nguyen Van Thuc,

Vu Hong Thai,

Nguyễn Thu Hương,

Nguyen Ngoc Ba,

Pham Xuan Khoa,

Erwin Schurr,

Laurent Abel,

Alexandre Alcaïs

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/521684

Subject(s) - biology , genetic linkage , immunology , genetics , gene

The Mitsuda reaction, a delayed granulomatous skin reaction elicited by the intradermal injection of heat-killed Mycobacterium leprae, is an in vivo test reflecting the ability to generate an immune granuloma after sensitization by diverse mycobacterial infections. Accumulating evidence for the genetic control of the Mitsuda reaction has been reported. We performed a genomewide linkage scan for the quantitative Mitsuda reaction in 19 large families from Vietnam with a history of leprosy (114 offspring). Suggestive linkage was found at chromosomal regions 2q35 (P = 9 x 10(-4) at the SLC11A1 locus) and 17q21-25 (P = 8 x 10(-4)). Interestingly, these 2 regions have been previously linked to mycobacterial infection and other granulomatous diseases.

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