Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan | Zendy

Selma M. B. Jerônimo | Zendy; Priya Duggal | Zendy; Nicholas Ettinger | Zendy; Eliana T. Nascimento | Zendy; Glória R. Monteiro | Zendy; Angela P. Cabral | Zendy; Núbia N. Pontes | Zendy; Hênio Godeiro Lacerda | Zendy; Paula V.S. Queiroz | Zendy; Carlos Eduardo Maia Gomes | Zendy; Richard D. Pearson | Zendy; Jenefer M. Blackwell | Zendy; Terri H. Beaty | Zendy; Mary E. Wilson | Zendy

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Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Author(s) -

Selma M. B. Jerônimo,

Priya Duggal,

Nicholas Ettinger,

Eliana T. Nascimento,

Glória R. Monteiro,

Angela P. Cabral,

Núbia N. Pontes,

Hênio Godeiro Lacerda,

Paula V.S. Queiroz,

Carlos Eduardo Maia Gomes,

Richard D. Pearson,

Jenefer M. Blackwell,

Terri H. Beaty,

Mary E. Wilson

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/521682

Subject(s) - leishmania chagasi , visceral leishmaniasis , immunology , asymptomatic , biology , leishmaniasis , leishmania , disease , genetic linkage , virology , genetics , medicine , parasite hosting , pathology , gene , world wide web , computer science

The protozoan Leishmania chagasi can cause disseminated, fatal visceral leishmaniasis (VL) or asymptomatic infection in humans. We hypothesized that host genetic factors contribute to this variable response to infection. A family study was performed in neighborhoods of endemicity for L. chagasi near Natal in northeastern Brazil. Study subjects were assessed for the presence of VL or asymptomatic infection, which was defined by a positive delayed-type hypersensitivity (DTH) skin test response to Leishmania antigen without disease symptoms. A genomewide panel of 385 autosomal microsatellite markers in 1254 subjects from 191 families was analyzed to identify regions of linkage. Regions with potential linkage to the DTH response on chromosomes 15 and 19, as well as a novel region on chromosome 9 with potential linkage to VL, were identified. Understanding the genetic factors that determine whether an individual will develop symptomatic or asymptomatic infection with L. chagasi may identify proteins essential for immune protection against this parasitic disease and reveal strategies for immunotherapy or prevention.

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