Relationship between the Quantity of Kaposi Sarcoma–Associated Herpesvirus (KSHV) in Peripheral Blood and Effusion Fluid Samples and KSHV‐Associated Disease | Zendy

AnneGeneviève Marcelin | Zendy; Jérome Motol | Zendy; Amélie Guihot | Zendy; Éric Caumes | Zendy; JeanPaul Viard | Zendy; Élisabeth Dussaix | Zendy; Jacquès Cadranel | Zendy; Camille Françès | Zendy; Guislaine Carcelain | Zendy; Vincent Cálvez | Zendy; N. Dupin | Zendy

Open Access

Relationship between the Quantity of Kaposi Sarcoma–Associated Herpesvirus (KSHV) in Peripheral Blood and Effusion Fluid Samples and KSHV‐Associated Disease

Author(s) -

AnneGeneviève Marcelin,

Jérome Motol,

Amélie Guihot,

Éric Caumes,

JeanPaul Viard,

Élisabeth Dussaix,

Jacquès Cadranel,

Camille Françès,

Guislaine Carcelain,

Vincent Cálvez,

N. Dupin

Publication year - 2007

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/521625

Subject(s) - primary effusion lymphoma , kaposi's sarcoma associated herpesvirus , sarcoma , kaposi's sarcoma , lymphoma , effusion , medicine , human herpesvirus , virology , pathology , pleural effusion , virus , gastroenterology , viral disease , immunology , herpesviridae , surgery

The Kaposi sarcoma-associated herpesvirus (KSHV)-DNA level was determined in samples from 71 patients with Kaposi sarcoma (KS), 28 patients with multicentric Castleman disease (MCD), and 8 patients with primary effusion lymphoma (PEL). KSHV-DNA levels were higher in patients with active KS or MCD than in those with KS or MCD in remission. Among patients with active disease, the highest KSHV-DNA levels were observed in effusion fluid samples from patients with PEL (7.2 log(10) copies/150,000 cells), followed by blood samples from patients with MCD and PEL (4.86 and 3.83 log(10) copies/150,000 cells, respectively), and the lowest levels were observed in blood samples from patients with KS (2.63 log(10) copies/150,000 cells). Determining the KSHV-DNA level may be useful in diagnosing KSHV-associated disease and for following up patients with KS when the development of MCD or PEL is suspected.

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