Open AccessUnique Lipid A Modifications inPseudomonas aeruginosaIsolated from the Airways of Patients with Cystic Fibrosis
Author(s) -
Robert K. Ernst,
Samuel M. Moskowitz,
Julia Emerson,
Gretchen M. Kraig,
Kristin N. Adams,
Megan D. Harvey,
Bonnie W. Ramsey,
David P. Speert,
Jane L. Burns,
Samuel I. Miller
Publication year - 2007
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/521367
Subject(s) - pseudomonas aeruginosa , cystic fibrosis , microbiology and biotechnology , residue (chemistry) , fatty acid , bacteria , biology , chemistry , biochemistry , medicine , genetics
Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n=86), from the environment (n=13), and from patients with other conditions (n=14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.
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